Article
GWAS signals revisited using human knockouts.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2018
Maddirevula Sateesh, AlZahrani Fatema, Anazi Shams, Almureikhi Mariam, Ben-Omran Tawfeg, Abdel-Salam Ghada M H, Hashem Mais, Ibrahim Niema, Abdulwahab Firdous M, Meriki Neama, Bashiri Fahad A, Thong Meow-Keong, Muthukumarasamy Premala, Azwani Mazlan Rifhan, Shaheen Ranad, Alkuraya Fowzan S
Abstract excerpt
PurposeGenome-wide association studies (GWAS) have been instrumental to our understanding of the genetic risk determinants of complex traits. A common challenge in GWAS is the interpretation of signals, which are usually attributed to the genes closest to the polymorphic markers that display the strongest statistical association. Naturally occurring complete loss of function (knockout) of these genes in humans...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.