Article
Nuclear Factor Kappa B (NF-κB)1 and NF-κB2 Deficiency: An Unpredictable Defect With Wide Clinical and Immunologic Phenotype.
Scandinavian journal of immunology - 1 Sept 2026
Sevinç Selin, İslamoğlu Candan, Haskoloğlu Şule, Öztürk Gökcan, Bal Sevgi Köstel, Aslan Ayşen Durak, Şahap Seda Kaynak, Ersöz Cevriye Cansız, Kendirli Tanıl, Doğu Figen, İkincioğulları Aydan
Abstract excerpt
The Nuclear Factor Kappa B (NF-kB) signalling pathway is essential for regulating inflammation, cell survival, and adaptive immune responses through its canonical (NF-κB1-associated) and noncanonical (NF-κB2-associated) branches. The canonical pathway mediates rapid and broad reactions to immune stimuli, whereas the noncanonical pathway is activated by specific signals and contributes to lymphoid organ...
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