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Integrative proteo-transcriptomic characterization of advanced fibrosis in chronic liver disease across etiologies

30 Jan 2025

Abstract excerpt

Chronic hepatic injury and inflammation from various causes can lead to fibrosis and cirrhosis, potentially predisposing to hepatocellular carcinoma. The molecular mechanisms underlying fibrosis and its progression remain incompletely understood. Using a proteo-transcriptomics approach, we analyze liver and plasma samples from 330 individuals, including 40 healthy individuals and 290 patients with histologically...

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PMID: 39889710
DOI: 10.1016/j.xcrm.2025.101935

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