Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism

17 Jun 2025

Abstract excerpt

A Genome-wide association study (GWAS) on a European-American cohort identified chr11p11.2 as a neuroblastoma predisposition locus. Combining in-house and public genomic data from neuroblastoma cell lines, this work implicates rs2863002 as the candidate causal variant at the 11p11.2 locus, confirming its cis-regulatory activity through a luciferase reporter assay. The genetic association of rs2863002 with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Cancer Research Studies

Share to Neuroblastoma Research and Treatments

Source

Identifiers

PMID: 40525640
DOI: 10.1002/advs.202415181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid MetabolismPMID 40525640Read ↗

A genome-wide association study in Chinese children identifies and functionally validates 5q31.1 as a neuroblastoma susceptibility locusSemantic proximity Read ↗

Somatic Mutations Enriched in Cis-Regulatory Elements Affect Genes Involved in Embryonic Development and Immune System Response in Neuroblastoma.Semantic proximity Read ↗

Phenotype restricted genome-wide association study using a gene-centric approach identifies three low-risk neuroblastoma susceptibility Loci.Semantic proximity Read ↗

Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.Semantic proximity Read ↗

Integrative genomic analyses identify neuroblastoma risk genes involved in neuronal differentiation.Semantic proximity Read ↗

CFDP1 is a neuroblastoma susceptibility gene that regulates transcription factors of the noradrenergic cell identity.Semantic proximity Read ↗

The functional variant rs34330 of CDKN1B is associated with risk of neuroblastoma.Semantic proximity Read ↗

Regulatory non-coding somatic mutations as drivers of neuroblastomaSemantic proximity Read ↗

Integrative functional screen of genomic loci uncovers CCND2 and its genetic regulatory mechanism in colorectal cancer development.Semantic proximity Read ↗

Noncoding regulatory mutations contribute to the aberrant gene expression in neuroblastoma.Semantic proximity Read ↗

Chromosome 6p22 locus associated with clinically aggressive neuroblastoma.Semantic proximity Read ↗

Transcription Factors Involved in Tumorigenesis Are Over-Represented in Mutated Active DNA-Binding Sites in Neuroblastoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.