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Integrative genomic analyses identify neuroblastoma risk genes involved in neuronal differentiation.

Human genetics - 1 Nov 2024

Tirelli Matilde, Bonfiglio Ferdinando, Cantalupo Sueva, Montella Annalaura, Avitabile Marianna, Maiorino Teresa, Diskin Sharon J, Iolascon Achille, Capasso Mario

Abstract excerpt

Genome-Wide Association Studies (GWAS) have been decisive in elucidating the genetic predisposition of neuroblastoma (NB). The majority of genetic variants identified in GWAS are found in non-coding regions, suggesting that they can be causative of pathogenic dysregulations of gene expression. Nonetheless, pinpointing the potential causal genes within implicated genetic loci remains a major challenge. In this...

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Identifiers

PMID: 39192051
DOI: 10.1007/s00439-024-02700-2
PMCID: PMC11522082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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