Article
Phenotype restricted genome-wide association study using a gene-centric approach identifies three low-risk neuroblastoma susceptibility Loci.
PLoS genetics - 1 Mar 2011
Nguyen Le B, Diskin Sharon J, Capasso Mario, Wang Kai, Diamond Maura A, Glessner Joseph, Kim Cecilia, Attiyeh Edward F, Mosse Yael P, Cole Kristina, Iolascon Achille, Devoto Marcella, Hakonarson Hakon, Li Hongzhe K, Maris John M
Abstract excerpt
Neuroblastoma is a malignant neoplasm of the developing sympathetic nervous system that is notable for its phenotypic diversity. High-risk patients typically have widely disseminated disease at diagnosis and a poor survival probability, but low-risk patients frequently have localized tumors that are almost always cured with little or no chemotherapy. Our genome-wide association study (GWAS) has identified common...
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