Article
The role of membrane ERα signaling in bone and other major estrogen responsive tissues.
Scientific reports - 8 Jul 2016
Gustafsson K L, Farman H, Henning P, Lionikaite V, Movérare-Skrtic S, Wu J, Ryberg H, Koskela A, Gustafsson J-Å, Tuukkanen J, Levin E R, Ohlsson C, Lagerquist M K
Abstract excerpt
Estrogen receptor α (ERα) signaling leads to cellular responses in several tissues and in addition to nuclear ERα-mediated effects, membrane ERα (mERα) signaling may be of importance. To elucidate the significance, in vivo, of mERα signaling in multiple estrogen-responsive tissues, we have used female mice lacking the ability to localize ERα to the membrane due to a point mutation in the palmitoylation site...
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