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Article

Inactivation of estrogen receptor α in bone-forming cells induces bone loss in female mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2013

Määttä Jorma A, Büki Kalman G, Gu Guoliang, Alanne Maria H, Vääräniemi Jukka, Liljenbäck Heidi, Poutanen Matti, Härkönen Pirkko, Väänänen Kalervo

Abstract excerpt

The role of the estrogen receptor α (ERα) in bone-forming cells is incompletely understood at present. To examine the in vivo effects of ERα in these cells, we generated a mouse strain in which the ERα gene is inactivated in osteoblasts via osteocalcin promoter-regulated cyclic recombinase (Cre) activity (ERα(ΔOB/ΔOB)). This enabled micro-computed tomography- and histomorphometry-based analysis of ERα-mediated...

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Identifiers

PMID: 23073829
DOI: 10.1096/fj.12-213587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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