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Article

Closing the structure-to-function gap for LRRK2.

Trends in biochemical sciences - 1 Mar 2022

Tokars Valerie, Chen Chuyu, Parisiadou Loukia

Abstract excerpt

Variations in the LRRK2 gene represent one of the strongest genetic factors for Parkinson's disease (PD). It has become clear that structural knowledge of the encoded large multidomain LRRK2 protein will cast light on its biological function. The new study from Myasnikov, Zhu, et al. provides a high-resolution structure of the full-length LRRK2.

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Identifiers

PMID: 34756665
DOI: 10.1016/j.tibs.2021.10.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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