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Analysis of Hyperexpanded T Cell Clones in SARS ‐ CoV ‐2 Vaccine‐Associated Liver Injury by Spatial Proteomics and Transcriptomics

16 Jun 2025

Abstract excerpt

BACKGROUND AND AIMS: SARS-CoV-2 vaccine-associated liver injury (SVALI) is a rare event and its pathophysiology remains unclear. Previous studies have found an oligoclonal CD8+ T cell infiltrate and SARS-CoV-2 spike antigen-specific T cells in the liver of patients with SVALI. Therefore, we aimed to characterise the immune infiltrate in a liver explant from a patient with severe SVALI. METHODS: T cell receptor...

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PMID: 40522253
DOI: 10.1111/liv.70172

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