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Article

Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies

2026-04-09

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 persistence is a proposed driver of Long COVID (LC), but the in-situ relationship between residual viral antigen and immune dysregulation remains poorly defined. To address this critical gap, we employed a high-resolution, multi-modal approach—combining RNAscope, GeoMx Digital Spatial Profiling (DSP), spatial transcriptomics, and multiplex immunofluorescence—on 25 terminal il...

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Identifiers and source

Literature Corpus work
3847f088-e215-5e15-97df-f576c698063a
DOI
10.21203/rs.3.rs-9284759/v1
Open publication

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Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut BiopsiesDOI 10.21203/rs.3.rs-9284759/v1
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