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Ag-driven CD8+ T cell clonal expansion is a prominent feature of MASH in humans and mice

24 Jul 2024

Abstract excerpt

BACKGROUND AND AIMS: Chronic liver disease due to metabolic dysfunction-associated steatohepatitis (MASH) is a rapidly increasing global epidemic. MASH progression is a consequence of the complex interplay between inflammatory insults and dysregulated hepatic immune responses. T lymphocytes have been shown to accumulate in the liver during MASH, but the cause and consequence of T cell accumulation in the liver...

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PMID: 39047085
DOI: 10.1097/hep.0000000000000971

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