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Dynamics of mitochondrial DNA copy number regulation in relation to gastric cancer survival

13 Jun 2025

Abstract excerpt

PURPOSE: To investigate the causal effects of gene expression levels associated with mitochondrial DNA copy number (mtDNA-CN) on cancer survival outcomes. METHODS: We performed two-sample mendelian randomization (MR) analyses to evaluate the causal relationship between mtDNA-CN in peripheral blood and overall survival period of different cancer types. Additionally, colocalization analyses were performed to...

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PMID: 40514632
DOI: 10.1007/s12672-025-02825-4

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