Article
Mitochondrial DNA copy number and risk of gastric cancer: a report from the Shanghai Women's Health Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2011
Liao Linda M, Baccarelli Andrea, Shu Xiao-Ou, Gao Yu-Tang, Ji Bu-Tian, Yang Gong, Li Hong-Lan, Hoxha Mirjam, Dioni Laura, Rothman Nathaniel, Zheng Wei, Chow Wong-Ho
Abstract excerpt
BACKGROUND: Mitochondrial DNA (mtDNA) is an approximately 16,000-bp circular double-stranded DNA molecule that is a prime target of oxidative damage. Several somatic mutations in mtDNA have been observed in gastric tumors, suggesting an involvement in gastric cancer risk and progression. mtDNA copy number in leukocyte DNA has also been linked to several other cancers, although the temporal relationship between...
Topics
- Adult
- Aged
- Case-Control Studies
- Cohort Studies
- DNA Copy Number Variations
- DNA, Mitochondrial
- Female
- Genetic Predisposition to Disease
- Humans