Article
Demographic history and rare allele sharing among human populations.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2011
Gravel Simon, Henn Brenna M, Gutenkunst Ryan N, Indap Amit R, Marth Gabor T, Clark Andrew G, Yu Fuli, Gibbs Richard A, Bustamante Carlos D
Abstract excerpt
High-throughput sequencing technology enables population-level surveys of human genomic variation. Here, we examine the joint allele frequency distributions across continental human populations and present an approach for combining complementary aspects of whole-genome, low-coverage data and targeted high-coverage data. We apply this approach to data generated by the pilot phase of the Thousand Genomes Project,...
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