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Article

Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion

20 May 2021

Abstract excerpt

PURPOSE: We previously demonstrated that sex influences response to immune checkpoint inhibitors. In this article, we investigate sex-based differences in the molecular mechanisms of anticancer immune response and immune evasion in patients with NSCLC. EXPERIMENTAL DESIGN: We analyzed (i) transcriptome data of 2,575 early-stage NSCLCs from seven different datasets; (ii) 327 tumor samples extensively characterized...

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PMID: 34016641
DOI: 10.1158/1078-0432.ccr-21-0136

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