Article
The R203M and D377Y mutations of the nucleocapsid protein promote SARS-CoV-2 infectivity by impairing RIG-I-mediated antiviral signaling.
PLoS pathogens - 1 Jan 2025
Li Yongkui, Li Moran, Xiao Heng, Liao Feng, Shen Miaomiao, Ge Weiwei, Ou Junxian, Liu Yuqing, Chen Lumiao, Zhao Yue, Wan Pin, Liu Jinbiao, Chen Jun, Lan Xianwu, Wu Shaorong, Ding Qiang, Li Geng, Zhang Qiwei, Pan Pan
Abstract excerpt
The viral protein mutations can modify virus-host interactions during virus evolution, and thus alter the extent of infection or pathogenicity. Studies indicate that nucleocapsid (N) protein of SARS-CoV-2 participates in viral genome assembly, intracellular signal regulation and immune interference. However, its biological function in viral evolution is not well understood. SARS-CoV-2 N protein mutations were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.