Article

Evolution of the SARS-CoV-2 mutational spectrum

2022-11-21

Abstract excerpt

SARS-CoV-2 evolves rapidly in part because of its high mutation rate. Here we examine whether this mutational process itself has changed during viral evolution. To do this, we quantify the relative rates of different types of single nucleotide mutations at four-fold degenerate sites in the viral genome across millions of human SARS-CoV-2 sequences. We find clear shifts in the relative rates of several types of mut...

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Literature Corpus work: 3c7e4d2d-a113-5da6-91de-088a2a9528a6
DOI: 10.1101/2022.11.19.517207

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