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Article

Evolution of the SARS-CoV-2 Mutational Spectrum.

Molecular biology and evolution - 4 Apr 2023

Bloom Jesse D, Beichman Annabel C, Neher Richard A, Harris Kelley

Abstract excerpt

SARS-CoV-2 evolves rapidly in part because of its high mutation rate. Here, we examine whether this mutational process itself has changed during viral evolution. To do this, we quantify the relative rates of different types of single-nucleotide mutations at 4-fold degenerate sites in the viral genome across millions of human SARS-CoV-2 sequences. We find clear shifts in the relative rates of several types of...

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Identifiers

PMID: 37039557
DOI: 10.1093/molbev/msad085
PMCID: PMC10124870

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