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Article

Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain.

Molecular cell - 19 Jun 2025

Hu Jie, Li Xiao, Lomaev Dmitry, Vorobyeva Nadezhda E, Levine Michael, Erokhin Maksim, Chetverina Darya

Abstract excerpt

Drosophila tethering elements mediate long-range enhancer-promoter interactions and connect the promoters of distant paralogous genes. Micro-C maps identified 645 such loops in the Drosophila larval brain, spanning distances of 25 to 250 kb. Here, we demonstrate that the MADF-containing Vostok protein acts as a looping factor. It binds to GCAACA motifs that are overrepresented in brain tethering elements. There...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40499548
DOI: 10.1016/j.molcel.2025.05.020
PMCID: PMC12377424

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