Article
Impacts of the ubiquitous factor Zelda on Bicoid-dependent DNA binding and transcription in Drosophila.
Genes & development - 15 Mar 2014
Xu Zhe, Chen Hongtao, Ling Jia, Yu Danyang, Struffi Paolo, Small Stephen
Abstract excerpt
In vivo cross-linking studies suggest that the Drosophila transcription factor Bicoid (Bcd) binds to several thousand sites during early embryogenesis, but it is not clear how many of these binding events are functionally important. In contrast, reporter gene studies have identified >60 Bcd-dependent enhancers, all of which contain clusters of the consensus binding sequence TAATCC. These studies also identified...
Topics
- Amino Acid Motifs
- Animals
- Drosophila Proteins
- Drosophila melanogaster
- Embryo, Nonmammalian
- Enhancer Elements, Genetic
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Mutation
- Nuclear Proteins
- Protein Binding
- Trans-Activators
- Transcription Factors