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Longitudinal analysis of gut microbiome and metabolome correlates of response and toxicity with idecabtagene vicleucel

8 Apr 2025

Abstract excerpt

ABSTRACT: Increasing evidence suggests that the gut microbiome may influence the responses and toxicities associated with chimeric antigen receptor T-cell (CAR-T) therapy. We conducted whole-genome shotgun sequencing on stool samples (N = 117) collected at various times from patients with multiple myeloma (n = 33) who underwent idecabtagene vicleucel (ide-cel) anti-B-cell maturation antigen CAR-T therapy. We...

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PMID: 40198765
DOI: 10.1182/bloodadvances.2024014476

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