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Article

SIRT5 functions as a tumor suppressor in renal cell carcinoma by reversing the Warburg effect

1 Dec 2021

Abstract excerpt

BACKGROUND: The aim of this study was to investigate the biological functions and underlying mechanisms of SIRT5 in clear cell renal cell carcinoma (ccRCC). METHODS: SIRT5 expression data in The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) were selected, and the correlations between SIRT5 expression and various clinicopathological parameters were analysed. SIRT5 expression in ccRCC tissues was...

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PMID: 34930316
DOI: 10.1186/s12967-021-03178-6

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