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Article

A Revised Molecular Model of Ovarian Cancer Biomarker CA125 (MUC16) Enabled by Long-read Sequencing

10 Jan 2024

Abstract excerpt

The biomarker CA125, a peptide epitope located in several tandem repeats of the mucin MUC16, is the gold standard for monitoring regression and recurrence of high-grade serous ovarian cancer in response to therapy. However, the CA125 epitope along with several structural features of the MUC16 molecule are ill defined. One central aspect still unresolved is the number of tandem repeats in MUC16 and how many of...

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PMID: 38197671
DOI: 10.1158/2767-9764.crc-23-0327

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A Revised Molecular Model of Ovarian Cancer Biomarker CA125 (MUC16) Enabled by Long-read SequencingPMID 38197671Read ↗

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