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Article

Analyzing fourteen deleterious nsSNPs of CFTR as promising genetic markers for cancer prognosis.

Scientific reports - 31 Mar 2026

Abbas Seyyedha, Shabbir Maria, Badshah Yasmin, Abid Fizzah, Khan Khushbukhat, Hafeez Amna, Ashraf Naeem Mahmood, Trembley Janeen H, Afsar Tayyaba, Khan Altaf, Fatima Sadia, Razak Suhail

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel protein involved in trans-epithelial transport of salt and the regulation of intracellular ion concentrations. The present study aims to investigate the relationship between CFTR non-synonymous SNPs (nsSNPs) and cancer. The study also seeks to elucidate the structural and functional consequences of the deleterious CFTR variants on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41917079
DOI: 10.1038/s41598-026-45158-0
PMCID: PMC13106712

Genes

CFTR

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