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Crystal structure of a human MUC16 SEA domain reveals insight into the nature of the CA125 tumor marker

17 Jan 2022

Abstract excerpt

MUC16 is a membrane bound glycoprotein involved in the progression and metastasis of pancreatic and ovarian cancer. The protein is shed into the serum and the resulting cancer antigen 125 (CA125) can be detected by immunoassays. The CA125 epitope is used for monitoring ovarian cancer treatment progression, and has emerged as a potential target for antibody mediated immunotherapy. The extracellular tandem repeat...

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PMID: 35037700
DOI: 10.1002/prot.26303

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