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Article

Integrative structural and functional analysis of nsSNPs in AP1S1, CERCAM, and SLC34A2 reveals novel therapeutic targets in lung adenocarcinoma.

Computational biology and chemistry - 1 Dec 2026

Robinson Binisha, Kushal Amish, Hanna Luke Elizabeth, Piramanayagam Shanmughavel

Abstract excerpt

Lung adenocarcinoma (LUAD), a leading type of non-small cell lung cancer, exhibits considerable molecular diversity due to genetic, epigenetic, and transcriptomic alterations, which affect tumour progression, treatment efficacy, and prognosis. This study systematically investigates non-synonymous single-nucleotide polymorphisms (nsSNPs) in potential biomarker genes AP1S1, CERCAM, and SLC34A2 using in silico...

Read the complete abstract on PubMed

Topics

Humans
Lung Neoplasms
Polymorphism, Single Nucleotide
Adenocarcinoma of Lung
Sodium-Phosphate Cotransporter Proteins, Type IIb

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Antineoplastic Agents

Adenocarcinoma

Mitoxantrone

Source

Identifiers

PMID: 42541864
DOI: 10.1016/j.compbiolchem.2026.109277

Genes

AP1S1
CERCAM
SLC34A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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