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Neuroinflammation associated with proviral DNA persists in the brain of virally suppressed people with HIV

21 May 2025

Abstract excerpt

Despite viral suppression with antiretroviral therapy (ART), people with HIV (PWH) continue to exhibit brain pathology, and ~20% of individuals develop HIV-associated neurocognitive disorders. However, the state of cellular activation in the brain of virally suppressed (VS) PWH and the impact of local viral reservoirs on cellular activation are unclear. Using multiplex immunofluorescence imaging, here, we...

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PMID: 40469287
DOI: 10.3389/fimmu.2025.1570692

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