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Article

Expression profiling suggests microglial impairment in human immunodeficiency virus neuropathogenesis

25 Jan 2018

Abstract excerpt

Objective CD16+/CD163+ macrophages (MΦs) and microglia accumulate in the brains of patients with human immunodeficiency virus (HIV) encephalitis (HIVE), a neuropathological correlate of the most severe form of HIV‐associated neurocognitive disorders, HIV‐associated dementia. Recently, we found that some parenchymal microglia in brain of HIV+ subjects without encephalitis (HIV/noE) but with varying degrees of...

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PMID: 29369399
DOI: 10.1002/ana.25160

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