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Article

Associations Between Mosaic Loss of Sex Chromosomes and Incident Hospitalization for Atrial Fibrillation in the United Kingdom.

Journal of the American Heart Association - 19 Nov 2024

Lim Jungeun, Hubbard Aubrey K, Blechter Batel, Shi Jianxin, Zhou Weiyin, Loftfield Erikka, Machiela Mitchell J, Wong Jason Y Y

Abstract excerpt

BACKGROUND: Mosaic loss of chromosome Y (mLOY) in leukocytes of men reflects genomic instability from aging, smoking, and environmental exposures. A similar mosaic loss of chromosome X (mLOX) occurs among women. However, the associations between mLOY, mLOX, and risk of incident heart diseases are unclear. METHODS AND RESULTS: We estimated associations between mLOY, mLOX, and risk of incident heart diseases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39508149
DOI: 10.1161/JAHA.124.036984
PMCID: PMC11681411

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