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Article

Investigation and prediction of the severity of p53 mutants using parameters from structural calculations.

The FEBS journal - 1 Aug 2009

Carlsson Jonas, Soussi Thierry, Persson Bengt

Abstract excerpt

A method has been developed to predict the effects of mutations in the p53 cancer suppressor gene. The new method uses novel parameters combined with previously established parameters. The most important parameter is the stability measure of the mutated structure calculated using molecular modelling. For each mutant, a severity score is reported, which can be used for classification into deleterious and...

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Identifiers

PMID: 19558493
DOI: 10.1111/j.1742-4658.2009.07124.x
PMCID: PMC2730554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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