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ROWVA: A Structure-Based Metric for Predicting the Pathogenicity of Protein Variants Using Alphafold2.

Cancer science - 1 Jun 2026

Furutani Taiki, Okusha Yuka, Nagami Hiroki, Hanafusa Hiroko, Tomida Shuta, Sawada Ryusuke, Hosono Yasuyuki, Nakatochi Masahiro

Abstract excerpt

p53, an important tumor suppressor protein, functions as a tetramer. Therefore, malignant variants in the tetramer-forming domain increase the likelihood of p53 dysfunction. Recent developments in genome analysis technology have expanded our understanding of malignant variants. However, variants of uncertain significance are also being increasingly identified. Hence, methods to assess the pathogenicity of these...

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PMID: 41944209
DOI: 10.1111/cas.70380

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