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Label-free detection of ssDNA base insertion and deletion mutations by surface-enhanced Raman spectroscopy.

Analytical and bioanalytical chemistry - 1 Feb 2022

Zhang Yufeng, Zeng Jiayu, Huang Chao, Zhu Bixue, Zhang Qianjun, Chen Dongmei

Abstract excerpt

Surface-enhanced Raman spectroscopy (SERS), as a label-free, highly sensitive analytical method, has become an important tool for providing substance fingerprints. In this study, silver nanoparticles containing thiosulfate ions and calcium ions (Ag@SCNPs) have been used as an enhanced substrate to eliminate the interference of impurities on DNA signals. Intrinsic structural information on single-strand DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34825271
DOI: 10.1007/s00216-021-03799-2

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