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Article

Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2006

Chelu Mihail G, Goonasekera Sanjeewa A, Durham William J, Tang Wei, Lueck John D, Riehl Joyce, Pessah Isaac N, Zhang Pumin, Bhattacharjee Meenakshi B, Dirksen Robert T, Hamilton Susan L

Abstract excerpt

Malignant hyperthermia (MH) is a life-threatening disorder characterized by skeletal muscle rigidity and elevated body temperature in response to halogenated anesthetics such as isoflurane or halothane. Mutation of tyrosine 522 of RyR1 (the predominant skeletal muscle calcium release channel) to serine has been associated with human malignant hyperthermia. In the present study, mice created harboring this...

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Identifiers

PMID: 16284304
DOI: 10.1096/fj.05-4497fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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