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Article

Identification and quantification of gyrA variants in fluoroquinolone-resistant Mycobacterium tuberculosis in a MeltArray reaction.

Journal of clinical microbiology - 9 Jul 2025

Tu Chunxia, Su Biyi, Xiong Yunfan, Xia Zihan, Xiang Chunlin, Tan Yaoju, Xu Ye, Li Qingge

Abstract excerpt

Fluoroquinolones (FQs) resistance in Mycobacterium tuberculosis (MTB), primarily driven by mutations in the quinolone resistance-determining region (QRDR) of gyrA, poses a major concern in treating for multidrug-resistant tuberculosis (MDR-TB). These QRDR mutations are known to confer varying levels of resistance, leading to differences in treatment outcomes. Here, we introduced the MeltArray MTB/FQs assay, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40459255
DOI: 10.1128/jcm.00146-25
PMCID: PMC12239727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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