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Assessing fluoroquinolone resistance in Mycobacterium tuberculosis using nanopore sequencing: concordance with established diagnostic methods.

Infection - 1 Jun 2026

Ratnam Rashmi, Jain Parul, Abbas Faisal, Pandey Bhoopendra, Singh Manu, Singh Urmila, Kumar Vijay, Jain Amita, Kushwaha Ram Awadh Singh

Abstract excerpt

INTRODUCTION: Fluoroquinolones (FQs) are key components of World Health Organization (WHO)-recommended regimens for multidrug-resistant tuberculosis (MDR-TB). Accurate detection of FQ resistance is essential for optimizing treatment. This study evaluated the concordance between the Second-Line Line Probe Assay (SL-LPA) and Liquid Culture Drug Susceptibility Testing (LC-DST) for detecting FQ resistance in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42018131
DOI: 10.1007/s15010-026-02798-8

Genes

LPA
DST

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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