Article
Molecular diagnosis of fluoroquinolone resistance in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy - 1 Mar 2015
Bernard Christine, Veziris Nicolas, Brossier Florence, Sougakoff Wladimir, Jarlier Vincent, Robert Jérôme, Aubry Alexandra
Abstract excerpt
As a consequence of the use of fluoroquinolones (FQ), resistance to FQ has emerged, leading to cases of nearly untreatable and extensively drug-resistant tuberculosis. Mutations in DNA gyrase represent the main mechanism of FQ resistance. A full understanding of the pattern of mutations found in FQ-resistant (FQ(r)) clinical isolates, and of their proportions, is crucial for improving molecular methods for the...
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