Article
Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug-Resistant Tuberculosis.
Journal of clinical microbiology - 1 Sept 2018
de Vos Margaretha, Derendinger Brigitta, Dolby Tania, Simpson John, van Helden Paul D, Rice John E, Wangh Lawrence J, Theron Grant, Warren Robin M
Abstract excerpt
Most cases of multidrug-resistant (MDR) tuberculosis (TB) are never diagnosed (328,300 of the ∼490,000 cases in 2016 were missed). The Xpert MTB/RIF assay detects resistance only to rifampin, despite ∼20% of rifampin-resistant cases being susceptible to isoniazid (a critical first-line drug). Consequently, many countries require further testing with the GenoType MTBDRplus assay. However, MTBDRplus is not...
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