Article
Longitudinal and multisite sampling reveals mutational and copy number evolution in tumors during metastatic dissemination.
Nature genetics - 1 Jun 2025
Zhao Karena, Vos Joris, Lam Stanley, Boe Lillian A, Muldoon Daniel, Han Catherine Y, Valero Cristina, Lee Mark, Fitzgerald Conall, Lee Andrew S, Prasad Manu, Jain Swati, Deng Xinzhu, Chan Timothy A, Berger Michael F, Bandlamudi Chaitanya, Zhou Xi Kathy, Morris Luc G T
Abstract excerpt
To understand genetic evolution in cancer during metastasis, we analyzed genomic profiles of 3,732 cancer patients in whom several tumor sites were longitudinally biopsied. During distant metastasis, tumors were observed to accumulate copy number alterations (CNAs) to a much greater degree than mutations. In particular, the development of whole genome duplication was a common event during metastasis, emerging de...
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