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Article

A novel variant in TLE6 is associated with embryonic developmental arrest (EDA) in familial female infertility.

Scientific reports - 21 Oct 2022

Akbari Mojdeh, Mohebi Mehdi, Berjis Katayon, Ghahremani Amin, Modarressi Mohammad Hossein, Ghafouri-Fard Soudeh

Abstract excerpt

This study aims to identify genetic causes of familial female infertility characterized by embryonic developmental arrest (EDA) and repeated implantation failure (RIF) with oocyte donation IVF cycle. We used Whole-exome sequencing and Sanger validation to find causative genes in an Iranian consanguineous family that had 3 infertile daughters, 4 fertile daughters, and 2 fertile sons. All patients in this...

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Identifiers

PMID: 36271123
DOI: 10.1038/s41598-022-22687-y
PMCID: PMC9587212

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A novel variant in TLE6 is associated with embryonic developmental arrest (EDA) in familial female infertility.PMID 36271123Read ↗

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