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French guidelines for the diagnosis and management of pure hereditary spastic paraplegia

30 May 2025

Abstract excerpt

INTRODUCTION: Hereditary spastic paraplegia (HSP) describes a group of rare genetic neurological diseases characterized by a common clinical presentation made of progressive motor weakness and spasticity of the lower limbs. The global prevalence is estimated at 3.6 individuals per 100,000 inhabitants. CLINICAL: The age of onset of first symptoms, the severity and the rate of progression are highly variable...

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PMID: 40450402
DOI: 10.1016/j.neurol.2025.05.001

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