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Article

SNP-associated differential methylation in ARHGEF38: insights into genetic-epigenetic interactions.

Epigenomics - 1 Jun 2025

Kovács Emese H C, Casten Lucas G, Mullins Niamh, Richards Jenny Gringer, Williams Aislinn J, Wemmie John A, Magnotta Vincent A, Fiedorowicz Jess G, Michaelson Jacob, Gaine Marie E

Abstract excerpt

OBJECTIVE: Associations have been seen between suicide and differential DNA methylation, with one study showing significant hypomethylation of ARHGEF38 in individuals with bipolar disorder who died by suicide. Our objective was to explore ARHGEF38 methylation in individuals with bipolar disorder and a history of suicide attempt. METHOD: With pyrosequencing, we looked at the previously identified region of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40444651
DOI: 10.1080/17501911.2025.2513215
PMCID: PMC12143701

Genes

ARHGEF38

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