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Article

Cyst fluid ctDNA as a biomarker for genetic profiling and treatment monitoring in cystic brain metastases.

British journal of cancer - 1 Aug 2025

Zhang Zhen, Jin Xingyu, Yin Qiang, Li Peng, Sun Zengfeng, Li Wenliang, Liu Qun, Zhang Xiaohui, Wang Peng, Piao Yingzhe, Lu Yalin, Li Lianwang, Yi Kaikai, She Chunhua, Ma Li, Zhang Jiangyan, Jin Xun, Cao Manqing, Wang Xiaoguang

Abstract excerpt

BACKGROUND: Cystic brain metastases (CBM) present significant clinical challenges due to their heterogeneity and the limitations of current diagnostic methods in guiding treatment. Traditional tissue biopsies are invasive and may not capture tumour heterogeneity, while plasma circulating tumour DNA (ctDNA) analysis is impeded by the blood-brain barrier, leading to low sensitivity for detecting intracranial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40442404
DOI: 10.1038/s41416-025-03047-9
PMCID: PMC12322235

Genes

EGFR
TP53

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