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ANT1 Deficiency Impairs Macrophage Metabolism and Migration, Protecting Against Emphysema in Chronic Obstructive Pulmonary Disease

29 May 2025

Abstract excerpt

Abstract Macrophage-mediated inflammation drives various lung diseases, including chronic obstructive pulmonary disease (COPD). COPD macrophages have dysfunctional mitochondrial metabolism and function, which lead to a chronic inflammatory lung environment. However, the factors regulating this altered metabolism have not been elucidated. ANT1 (adenine nucleotide translocase 1) is a mitochondrial ATP transporter...

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PMID: 40439531
DOI: 10.1165/rcmb.2024-0469oc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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