Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejection

22 May 2025

Abstract excerpt

Graft endothelial cells (ECs) express donor alloantigens and encounter cytotoxic T lymphocytes (CTLs) but are generally spared during T cell-mediated rejection (TCMR), which predominantly affects epithelial structures. The mechanisms underlying this vascular immune privilege are unclear. Transcriptomics analyses and endothelial-mesenchymal transition assessments confirmed that the graft endothelium was preserved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine receptors and signaling
Share to Immunotherapy and Immune Responses
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40435228
DOI: 10.1172/jci155191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejectionPMID 40435228Read ↗

Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolutionSemantic proximity Read ↗

Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomesSemantic proximity Read ↗

Adaptive Immune Landscape of T-Cell Mediated Rejection of Human Kidney AllograftsSemantic proximity Read ↗

A Gene-expression Module Identifies Circulating Immune Cells with Enhanced Recruitment to Sites of InflammationSemantic proximity Read ↗

Significant Differences in Antigen-Induced Transendothelial Migration of Human CD8 and CD4 T Effector Memory Cells.Semantic proximity Read ↗

Transplantation: molecular phenotyping of T-cell-mediated rejection.Semantic proximity Read ↗

The role of the graft endothelium in transplant rejection: Evidence that endothelial activation may serve as a clinical marker for the development of chronic rejectionSemantic proximity Read ↗

Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunitySemantic proximity Read ↗

Virus-specific TRM cells of both donor and recipient origin reside in human kidney transplantsSemantic proximity Read ↗

Thick ascending limb injury critically impacts kidney allograft survival after T-cell-mediated rejectionSemantic proximity Read ↗

Effector Memory–Expressing CD45RA (TEMRA) CD8+ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor–Dependent Proinflammatory and Migratory ResponsesSemantic proximity Read ↗

Spatial transcriptomic profiling of vascular compartments of chronic antibody-mediated rejection in kidney allografts identified compartment-specific signatures: a pilot studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.