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Ferroptosis and EMT: key targets for combating cancer progression and therapy resistance

19 Aug 2023

Abstract excerpt

) and lipid peroxidation, of which are controlled by glutathione peroxidase 4 (GPX4). Its crucial role in stopping the spread of cancer has been shown by numerous studies undertaken in the last ten years. Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells acquire mesenchymal characteristics. EMT is connected to carcinogenesis, invasiveness, metastasis, and therapeutic resistance in...

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PMID: 37598126
DOI: 10.1007/s00018-023-04907-4

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