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Epigenetic modulation of ferroptosis in cancer: Identifying epigenetic targets for novel anticancer therapy

12 Jul 2023

Abstract excerpt

Ferroptosis is a newly recognized form of oxidative-regulated cell death resulting from iron-mediated lipid peroxidation accumulation. Radical-trapping antioxidant systems can eliminate these oxidized lipids and prevent disrupting the integrity of cell membranes. Epigenetic modifications can regulate ferroptosis by altering gene expression or cell phenotype without permanent sequence changes. These mechanisms...

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PMID: 37438601
DOI: 10.1007/s13402-023-00840-7

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