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Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics

27 May 2025

Abstract excerpt

Dysregulated cell death leading to uncontrolled cell proliferation is a hallmark of cancer. Chemotherapy-induced cell death is critical for the success of cancer treatment but this process is impaired by metabolic byproducts. How these byproducts interfere with anti-cancer therapy is unclear. Here, we show that the metabolic byproduct acrolein derived from polyamines, tobacco smoke or fuel combustion, induces...

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PMID: 40425585
DOI: 10.1038/s41467-025-60226-1

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