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Article

POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis

15 Jul 2025

Abstract excerpt

Evasion of programmed cell death (PCD) is a hallmark of cancer, yet the mechanisms underlying resistance to ferroptosis – an iron-dependent form of PCD triggered by excessive lipid peroxidation – remain incompletely understood. Here, we identify a previously unrecognized nucleolar-mitochondrial signaling axis that promotes ferroptosis resistance in pleural mesothelioma (PM) and potentially other cancers. This...

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PMID: 40669210
DOI: 10.1016/j.redox.2025.103758

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