[Spermine induces ferroptosis-related phenotype in acute myeloid leukemia cells through reactive oxygen species].

Abstract excerpt

Polyamines, including putrescine, spermidine, and spermine, are widely involved in various physiological processes in vivo. Their metabolic alterations are closely associated with tumor development, and interfering with polyamine metabolism has become a therapeutic strategy under investigation for cancer. However, studies have also demonstrated that spermine can inhibit the growth of castration-resistant prostate...

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